PF-06827443 Displays Robust Allosteric Agonist and Positive Allosteric Modulator Activity in High Receptor Reserve and Native Systems.

Moran SP, Cho HP, Maksymetz J, Remke DH, Hanson RM, Niswender CM, Lindsley CW, Rook JM, Conn PJ
ACS Chem Neurosci. 2018 9 (9): 2218-2224

PMID: 29683646 · PMCID: PMC6146053 · DOI:10.1021/acschemneuro.8b00106

MeSH Terms (15)

Allosteric Regulation Animals Calcium CHO Cells Cricetulus Dogs Humans Isoindoles Mice Oxazoles Patch-Clamp Techniques Prefrontal Cortex Rats Receptor, Muscarinic M1 Seizures

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