Discovery and Optimization of Potent and CNS Penetrant M-Preferring Positive Allosteric Modulators Derived from a Novel, Chiral N-(Indanyl)piperidine Amide Scaffold.

Bender AM, Cho HP, Nance KD, Lingenfelter KS, Luscombe VB, Gentry PR, Voigtritter K, Berizzi AE, Sexton PM, Langmead CJ, Christopoulos A, Locuson CW, Bridges TM, Chang S, O'Neill JC, Zhan X, Niswender CM, Jones CK, Conn PJ, Lindsley CW
ACS Chem Neurosci. 2018 9 (7): 1572-1581

PMID: 29678111 · PMCID: PMC6104635 · DOI:10.1021/acschemneuro.8b00126

MeSH Terms (14)

Allosteric Regulation Amides Animals Brain Cholinergic Agents Drug Discovery Humans Male Microsomes, Liver Molecular Structure Piperidines Rats, Sprague-Dawley Receptors, Muscarinic Structure-Activity Relationship

Connections (1)

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