Autochthonous tumors driven by loss have an ongoing requirement for the RBP2 histone demethylase.

McBrayer SK, Olenchock BA, DiNatale GJ, Shi DD, Khanal J, Jennings RB, Novak JS, Oser MG, Robbins AK, Modiste R, Bonal D, Moslehi J, Bronson RT, Neuberg D, Nguyen QD, Signoretti S, Losman JA, Kaelin WG
Proc Natl Acad Sci U S A. 2018 115 (16): E3741-E3748

PMID: 29610306 · PMCID: PMC5910822 · DOI:10.1073/pnas.1716029115

MeSH Terms (21)

Alleles Animals DNA-Binding Proteins Echocardiography Enzyme Activation Fibroblasts Genes, Retinoblastoma Heart Septal Defects Histone Code Integrases Jumonji Domain-Containing Histone Demethylases Mice Mice, Inbred C57BL Molecular Targeted Therapy Neoplasm Proteins Pituitary Neoplasms Recombinant Fusion Proteins Retinoblastoma Protein Tamoxifen Thyroid Neoplasms Transgenes

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