M-positive allosteric modulators lacking agonist activity provide the optimal profile for enhancing cognition.

Moran SP, Dickerson JW, Cho HP, Xiang Z, Maksymetz J, Remke DH, Lv X, Doyle CA, Rajan DH, Niswender CM, Engers DW, Lindsley CW, Rook JM, Conn PJ
Neuropsychopharmacology. 2018 43 (8): 1763-1771

PMID: 29581537 · PMCID: PMC6006294 · DOI:10.1038/s41386-018-0033-9

MeSH Terms (16)

Allosteric Regulation Animals CHO Cells Cholinergic Agents Cricetulus Excitatory Postsynaptic Potentials Male Mice, Inbred C57BL Nootropic Agents Prefrontal Cortex Pyramidal Cells Rats Rats, Sprague-Dawley Receptor, Muscarinic M1 Recognition, Psychology Tissue Culture Techniques

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