Prefrontal mediation of the reading network predicts intervention response in dyslexia.

Aboud KS, Barquero LA, Cutting LE
Cortex. 2018 101: 96-106

PMID: 29459284 · PMCID: PMC5869156 · DOI:10.1016/j.cortex.2018.01.009

A primary challenge facing the development of interventions for dyslexia is identifying effective predictors of intervention response. While behavioral literature has identified core cognitive characteristics of response, the distinction of reading versus executive cognitive contributions to response profiles remains unclear, due in part to the difficulty of segregating these constructs using behavioral outputs. In the current study we used functional neuroimaging to piece apart the mechanisms of how/whether executive and reading network relationships are predictive of intervention response. We found that readers who are responsive to intervention have more typical pre-intervention functional interactions between executive and reading systems compared to nonresponsive readers. These findings suggest that intervention response in dyslexia is influenced not only by domain-specific reading regions, but also by contributions from intervening domain-general networks. Our results make a significant gain in identifying predictive bio-markers of outcomes in dyslexia, and have important implications for the development of personalized clinical interventions.

Copyright © 2018 Elsevier Ltd. All rights reserved.

MeSH Terms (18)

Adolescent Analysis of Variance Biomarkers Brain Mapping Child Cognition Dyslexia Executive Function Female Humans Magnetic Resonance Imaging Male Nerve Net Prefrontal Cortex Reading Semantics Temporal Lobe Universities

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