Expression of the adenovirus E1A oncogene during cell transformation is sufficient to induce susceptibility to lysis by host inflammatory cells.

Cook JL, Walker TA, Lewis AM, Ruley HE, Graham FL, Pilder SH
Proc Natl Acad Sci U S A. 1986 83 (18): 6965-9

PMID: 2944117 · PMCID: PMC386632 · DOI:10.1073/pnas.83.18.6965

Mammalian cells transformed by nononcogenic human adenoviruses exhibit high susceptibility to destruction by host mononuclear inflammatory cells. We have analyzed the viral gene regulation of the susceptibility of transformed cells to lysis by natural killer cells and activated macrophages. Comparisons of target cell lines transformed by overlapping segments of the adenovirus E1-transforming gene region revealed that isolated expression of a single oncogene, E1A, was sufficient to cause increased cytolytic susceptibility in the absence of detectable transformed cell-surface expression of viral transplantation antigens and irrespective of histocompatibility antigen identity between killer cells and target cells. These results suggest that oncogene functions that are not linked to the expression of previously recognized cell-surface target structures may actively induce neoplastic cell elimination by components of the host immune surveillance system.

MeSH Terms (13)

Adenovirus Early Proteins Adenoviruses, Human Cell Line Cell Transformation, Neoplastic Cell Transformation, Viral Cytotoxicity, Immunologic Genes, Viral Killer Cells, Natural Macrophages Oncogene Proteins, Viral Oncogenes Phenotype RNA, Messenger

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