A Critical Need for Better Cancer Immunotherapy Models: Are Organotypic Tumor Spheroid Cultures the Answer?

Balko JM, Sosman JA
Cancer Discov. 2018 8 (2): 143-145

PMID: 29431673 · DOI:10.1158/2159-8290.CD-17-1356

Immunotherapy has transformed the therapeutic landscape of cancer, but the preclinical evaluation of combination approaches that will deepen and broaden its clinical benefit has lagged far behind due to the lack of expedient and easily accessible human systems. In this issue, Jenkins and colleagues and Deng and colleagues report the use of organotypic cultures of tumors derived from mice and humans containing both tumor cells and cells from their local immune microenvironment to recapitulate the use of immune checkpoint inhibitors and extend the application of this system to therapeutic combinations of immune checkpoint blockade and molecularly targeted agents. .

©2018 American Association for Cancer Research.

MeSH Terms (6)

Animals Humans Immunotherapy Mice Neoplasms Programmed Cell Death 1 Receptor

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