Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells.

Chung L, Thiele Orberg E, Geis AL, Chan JL, Fu K, DeStefano Shields CE, Dejea CM, Fathi P, Chen J, Finard BB, Tam AJ, McAllister F, Fan H, Wu X, Ganguly S, Lebid A, Metz P, Van Meerbeke SW, Huso DL, Wick EC, Pardoll DM, Wan F, Wu S, Sears CL, Housseau F
Cell Host Microbe. 2018 23 (2): 203-214.e5

PMID: 29398651 · PMCID: PMC5954996 · DOI:10.1016/j.chom.2018.01.007

MeSH Terms (26)

Adenomatous Polyposis Coli Protein Animals Bacterial Toxins Bacteroides fragilis Carcinogenesis Cell Line, Tumor Colon Colorectal Neoplasms Enzyme Activation Epithelial Cells Female Gene Deletion HT29 Cells Humans Inflammation Interleukin-17 Male Metalloendopeptidases Mice Mice, Inbred C57BL Mice, Knockout Myeloid Cells Receptors, Interleukin-8B Receptors, Interleukin-17 STAT3 Transcription Factor Transcription Factor RelA

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