Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 159 individuals from the Worcester region of the Western Cape province of South Africa.

Grifoni A, Sidney J, Carpenter C, Phillips E, Mallal S, Scriba TJ, Sette A, Lindestam Arlehamn CS
Hum Immunol. 2018 79 (3): 143-144

PMID: 29398200 · DOI:10.1016/j.humimm.2018.01.004

DNA sequence-based typing at the HLA-A, -B, -C, -DPA1, -DPB1, -DQA1, -DQB1, -DRB1, and -DRB3/4/5 loci was performed on samples provided by 159 individuals from the Worcester region of the Western Cape province of South Africa. The purpose of the study was to characterize allele frequencies in the local population, to support studies of T cell immunity against pathogens, including Mycobacterium tuberculosis. There are no detectable deviations from Hardy Weinberg proportions for the HLA-A, -B, -C, -DPA1, -DPB1, -DQA1, and -DRB1 loci. A minor deviation was detected at the HLA-DQB1 locus due to an excess of homozygotes. The genotype data are available in the Allele Frequencies Net Database under identifier 3425.

Copyright © 2018. Published by Elsevier Inc.

MeSH Terms (15)

Databases, Genetic Gene Frequency Genotype HLA-A Antigens HLA-B Antigens HLA-C Antigens HLA-DQ Antigens HLA-DR Antigens Humans Lymphocyte Activation Mycobacterium tuberculosis Sequence Analysis, DNA South Africa T-Lymphocytes Tuberculosis

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