Immunoregulation by T cells. I. Characterization of the IEk-specific Lbd self-reactive T cell clone that helps, suppresses and contrasupresses B cell responses.

Quintáns J, Suzuki H, Sosman JA, Shah PD
J Immunol. 1986 136 (6): 1974-81

PMID: 2936817

This paper describes an L3T4+, Lyt-2- cloned T cell line of CBA/N origin that is specific for IEk-encoded products. Splenic dendritic cells are the predominant stimulatory populations for Lbd cells, being approximately 100 times more effective than large activated B cells. Small B cells and T cells are nonstimulatory. Lbd cells help large B cells to make polyclonal antibody responses, but are unable to activate small B cells and to replace antigen-specific helper T cells in T cell-dependent responses to phosphorylcholine or sheep red blood cells. In the presence of antigen-specific helper T cells, Lbd can amplify, suppress, or contrasuppress T cell function, depending on the type and relative ratios of antigen-reactive cells. We explain our findings as a consequence of the self reactivity among helper T cells.

MeSH Terms (19)

Animals Antibodies, Monoclonal Antibody Formation Antigens, Differentiation, T-Lymphocyte Antigens, Ly Antigens, Surface B-Lymphocytes Clone Cells Histocompatibility Antigens Histocompatibility Antigens Class II Immune Tolerance Immunologic Memory Lymphocyte Activation Major Histocompatibility Complex Mice Mice, Inbred Strains T-Lymphocytes T-Lymphocytes, Helper-Inducer T-Lymphocytes, Regulatory

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