Poly(glycidol) Coating on Ultrahigh Molecular Weight Polyethylene for Reduced Biofilm Growth.

Lockhart JN, Spoonmore TJ, McCurdy MW, Rogers BR, Guelcher SA, Harth E
ACS Appl Mater Interfaces. 2018 10 (4): 4050-4056

PMID: 29345453 · PMCID: PMC5831121 · DOI:10.1021/acsami.7b15981

Semibranched poly(glycidol) (PG-OH) and poly(glycidol allylglycidyl ether) (PG-Allyl) coatings were formed on ultrahigh molecular weight polyethylene (UMWPE) in a unique two-step process which included radiation of UHMWPE followed by grafting of PG-OH or PG-Allyl to the surface via free radical cross-linking. Resulting surfaces were extensively characterized by FTIR-ATR, XPS, fluorescent microscopy, and contact goniometry. The performance was evaluated using the most prominent biofilm-forming bacteria Staphylococcus aureus for 24 and 48 h. The PG-Allyl coating demonstrated a 3 log reduction in biofilm growth compared to noncoated control, demonstrating a promising potential to inhibit adherence and colonization of biofilm-forming bacteria that often develop into persistent infections.

MeSH Terms (6)

Biofilms Coated Materials, Biocompatible Molecular Weight Polyethylenes Propylene Glycols Staphylococcus aureus

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