DNA methyltransferase inhibition upregulates MHC-I to potentiate cytotoxic T lymphocyte responses in breast cancer.

Luo N, Nixon MJ, Gonzalez-Ericsson PI, Sanchez V, Opalenik SR, Li H, Zahnow CA, Nickels ML, Liu F, Tantawy MN, Sanders ME, Manning HC, Balko JM
Nat Commun. 2018 9 (1): 248

PMID: 29339738 · PMCID: PMC5770411 · DOI:10.1038/s41467-017-02630-w

MeSH Terms (15)

Animals Antineoplastic Agents Azacitidine Breast Neoplasms Cell Line, Tumor DNA (Cytosine-5-)-Methyltransferase 1 Female Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Genes, MHC Class I Humans Mammary Neoplasms, Experimental Mice Promoter Regions, Genetic T-Lymphocytes, Cytotoxic

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