Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models.

Schulte ML, Fu A, Zhao P, Li J, Geng L, Smith ST, Kondo J, Coffey RJ, Johnson MO, Rathmell JC, Sharick JT, Skala MC, Smith JA, Berlin J, Washington MK, Nickels ML, Manning HC
Nat Med. 2018 24 (2): 194-202

PMID: 29334372 · PMCID: PMC5803339 · DOI:10.1038/nm.4464

MeSH Terms (15)

Amino Acid Transport System ASC Animals Cell Line, Tumor Cell Proliferation Computer Simulation Disease Models, Animal Glutamine HCT116 Cells Humans Mice Minor Histocompatibility Antigens Neoplasms Oxidative Stress Signal Transduction Small Molecule Libraries

Connections (4)

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