Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 714 adults from Colombo, Sri Lanka.

Grifoni A, Weiskopf D, Lindestam Arlehamn CS, Angelo M, Leary S, Sidney J, Frazier A, Phillips E, Mallal S, Mack SJ, Tippalagama R, Goonewardana S, Premawansa S, Premawansa G, Wijewickrama A, De Silva AD, Sette A
Hum Immunol. 2018 79 (2): 87-88

PMID: 29289740 · PMCID: PMC6378951 · DOI:10.1016/j.humimm.2017.12.007

DNA sequence-based typing at the HLA-A, -B, -C, -DPB1, -DQA1, -DQB1, and -DRB1 loci was performed on 714 healthy adult blood bank donors from Colombo, Sri Lanka, to characterize allele frequencies in support of studies on T cell immunity against pathogens, including Dengue virus. Deviations from Hardy Weinberg proportions were not detected at any locus. Several alleles were found in >30% of individuals, including the class II alleles DPB1 * 04:01, DPB1 * 02:01, DQB1 * 06:01 and DRB1 * 07:01, and the class I alleles A * 33:03 and A * 24:02. Genotype data will be available in the Allele Frequencies Net Database.

Copyright © 2018 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.

MeSH Terms (20)

Adult Animals Ethnic Groups Female Gene Frequency Genotype Healthy Volunteers Histocompatibility Testing HLA-A Antigens HLA-B Antigens HLA-C Antigens HLA-DP Antigens HLA-DQ Antigens HLA-DR Antigens Humans Male Mice Sequence Analysis, DNA Sri Lanka T-Lymphocytes

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