Development of Erasin: a chromone-based STAT3 inhibitor which induces apoptosis in Erlotinib-resistant lung cancer cells.

Lis C, Rubner S, Roatsch M, Berg A, Gilcrest T, Fu D, Nguyen E, Schmidt AM, Krautscheid H, Meiler J, Berg T
Sci Rep. 2017 7 (1): 17390

PMID: 29234062 · PMCID: PMC5727211 · DOI:10.1038/s41598-017-17600-x

MeSH Terms (16)

Antineoplastic Agents Apoptosis Carcinoma, Non-Small-Cell Lung Cell Line, Tumor Chromones Humans Lung Neoplasms Molecular Docking Simulation Phosphorylation Protein Processing, Post-Translational src Homology Domains STAT1 Transcription Factor STAT3 Transcription Factor STAT5 Transcription Factor Structure-Activity Relationship Tumor Suppressor Proteins

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