Experimental studies of g-ratio MRI in ex vivo mouse brain.

West KL, Kelm ND, Carson RP, Alexander DC, Gochberg DF, Does MD
Neuroimage. 2018 167: 366-371

PMID: 29208572 · PMCID: PMC5845846 · DOI:10.1016/j.neuroimage.2017.11.064

This study aimed to experimentally evaluate a previously proposed MRI method for mapping axonal g-ratio (ratio of axon diameters, measured to the inner and outer boundary of myelin). MRI and electron microscopy were used to study excised and fixed brains of control mice and three mouse models of abnormal white matter. The results showed that g-ratio measured with MRI correlated with histological measures of myelinated axon g-ratio, but with a bias that is likely due to the presence of non-myelinated axons. The results also pointed to cases where the MRI g-ratio model simplifies to be primarily a function of total myelin content.

Copyright © 2017 Elsevier Inc. All rights reserved.

MeSH Terms (10)

Animals Axons Brain Disease Models, Animal Magnetic Resonance Imaging Mice Mice, Knockout Microscopy, Electron Myelin Sheath White Matter

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