Non-visual arrestins regulate the focal adhesion formation via small GTPases RhoA and Rac1 independently of GPCRs.

Cleghorn WM, Bulus N, Kook S, Gurevich VV, Zent R, Gurevich EV
Cell Signal. 2018 42: 259-269

PMID: 29133163 · PMCID: PMC5732042 · DOI:10.1016/j.cellsig.2017.11.003

Arrestins recruit a variety of signaling proteins to active phosphorylated G protein-coupled receptors in the plasma membrane and to the cytoskeleton. Loss of arrestins leads to decreased cell migration, altered cell shape, and an increase in focal adhesions. Small GTPases of the Rho family are molecular switches that regulate actin cytoskeleton and affect a variety of dynamic cellular functions including cell migration and cell morphology. Here we show that non-visual arrestins differentially regulate RhoA and Rac1 activity to promote cell spreading via actin reorganization, and focal adhesion formation via two distinct mechanisms. Arrestins regulate these small GTPases independently of G-protein-coupled receptor activation.

Copyright © 2017 Elsevier Inc. All rights reserved.

MeSH Terms (18)

Actin Cytoskeleton Animals beta-Arrestin 1 beta-Arrestin 2 cdc42 GTP-Binding Protein Cell Adhesion Cell Line Cell Movement Fibroblasts Focal Adhesions Gene Expression Regulation Mice Neuropeptides rac1 GTP-Binding Protein Receptors, G-Protein-Coupled rhoA GTP-Binding Protein rho GTP-Binding Proteins Signal Transduction

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