The synthetic neuroactive steroid SGE-516 reduces seizure burden and improves survival in a Dravet syndrome mouse model.

Hawkins NA, Lewis M, Hammond RS, Doherty JJ, Kearney JA
Sci Rep. 2017 7 (1): 15327

PMID: 29127345 · PMCID: PMC5681541 · DOI:10.1038/s41598-017-15609-w

MeSH Terms (9)

Animals Anticonvulsants Epilepsies, Myoclonic GABA-A Receptor Agonists Hydroxycholesterols Mice Mice, Mutant Strains NAV1.1 Voltage-Gated Sodium Channel Receptors, GABA-A

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