Challenges in the development of an M PAM preclinical candidate: The discovery, SAR, and biological characterization of a series of azetidine-derived tertiary amides.

Tarr JC, Wood MR, Noetzel MJ, Melancon BJ, Lamsal A, Luscombe VB, Rodriguez AL, Byers FW, Chang S, Cho HP, Engers DW, Jones CK, Niswender CM, Wood MW, Brandon NJ, Duggan ME, Conn PJ, Bridges TM, Lindsley CW
Bioorg Med Chem Lett. 2017 27 (23): 5179-5184

PMID: 29089231 · PMCID: PMC6542369 · DOI:10.1016/j.bmcl.2017.10.053

MeSH Terms (9)

Allosteric Regulation Amides Azetidines Drug Evaluation, Preclinical Humans Protein Binding Pyridazines Receptor, Muscarinic M4 Structure-Activity Relationship

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