Pre-treatment with somatostatin in the anaesthetic management of a patient with carcinoid syndrome.

Parris WC, Oates JA, Kambam J, Shmerling R, Sawyers JF
Can J Anaesth. 1988 35 (4): 413-6

PMID: 2900085 · DOI:10.1007/BF03010865

Carcinoid syndrome produces flushing, bronchoconstriction and gastrointestinal hypermotility secondary to serotonin, histamine, bradykinin and prostaglandin release. A variety of drugs, foods and anaesthetic agents may provoke this syndrome. Under anaesthesia, the flushing produced may be associated with acute hypotension and cardiovascular collapse; this phenomenon is called a carcinoid crisis. Recently, somatostatin analogue has been used successfully to treat intraoperative carcinoid crisis. In this report, we present a 66-year-old lady with carcinoid syndrome who was pre-treated with 50 micrograms somatostatin analogue IV and IM prior to surgical manipulation. The anaesthetic course was relatively uneventful and the patient did well postoperatively.

MeSH Terms (11)

Aged Anesthesia, General Anesthesia, Inhalation Anesthesia, Intravenous Female Humans Ileal Neoplasms Malignant Carcinoid Syndrome Ovarian Neoplasms Premedication Somatostatin

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