Emerging biomarkers for cancer immunotherapy in melanoma.

Axelrod ML, Johnson DB, Balko JM
Semin Cancer Biol. 2018 52 (Pt 2): 207-215

PMID: 28917578 · PMCID: PMC5851807 · DOI:10.1016/j.semcancer.2017.09.004

The treatment and prognosis of metastatic melanoma has changed substantially since the advent of novel immune checkpoint inhibitors (ICI), agents that enhance the anti-tumor immune response. Despite the success of these agents, clinically actionable biomarkers to aid patient and regimen selection are lacking. Herein, we summarize and review the evidence for candidate biomarkers of response to ICIs in melanoma. Many of these candidates can be examined as parts of a known molecular pathway of immune response, while others are clinical in nature. Due to the ability of ICIs to illicit dramatic and durable responses, well-validated biomarkers that can be effectively implemented in the clinic will require strong negative predictive values that do not limit patients with who may benefit from ICI therapy.

Copyright © 2017 Elsevier Ltd. All rights reserved.

MeSH Terms (7)

Animals Antibodies, Monoclonal Biomarkers, Tumor Humans Immunotherapy Melanoma Tumor Microenvironment

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