Chloramphenicol use and childhood leukaemia in Shanghai.

Shu XO, Gao YT, Linet MS, Brinton LA, Gao RN, Jin F, Fraumeni JF
Lancet. 1987 2 (8565): 934-7

PMID: 2889862 · DOI:10.1016/s0140-6736(87)91420-6

A population-based case-control interview study of 309 childhood leukaemia cases and 618 age and sex matched controls showed a significant dose-response relation between chloramphenicol and risk of both acute lymphocytic leukaemia (ALL) and acute non-lymphocytic leukaemia (ANLL), treatment for more than 10 days being associated with risks of 11.0 and 12.0, respectively. A significant risk of ANLL was also observed with the use of syntomycin, a drug pharmacologically related to chloramphenicol. The risks remained high when analyses were limited to either first or latest use of these antibiotics more than 2 years before diagnosis. Although the association may have non-causal explanations, the results warrant cautious prescribing patterns and further investigations into the leukaemogenic potential of chloramphenicol.

MeSH Terms (12)

Child Child, Preschool China Chloramphenicol Dose-Response Relationship, Drug Humans Interviews as Topic Leukemia Leukemia, Lymphoid Leukemia, Myeloid, Acute Risk Time Factors

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