Stress-induced alterations in neurotensin, somatostatin and corticotropin-releasing factor in mesotelencephalic dopamine system regions.

Deutch AY, Bean AJ, Bissette G, Nemeroff CB, Robbins RJ, Roth RH
Brain Res. 1987 417 (2): 350-4

PMID: 2888514 · DOI:10.1016/0006-8993(87)90462-8

The effects of exposure to acute mild footshock stress on concentrations of neurotensin-, somatostatin-, and corticotropin-releasing factor-like immunoreactivity (li) in mesotelencephalic dopamine system regions of the rat were examined. Mild stress exposure resulted in a selective and regionally specific increase in neurotensin-li concentrations in the ventral tegmental area (VTA), source of the dopaminergic innervation of the mesocortical and mesolimbic dopaminergic terminal fields. Concentrations of somatostatin- or corticotropin-releasing factor-li were not changed in any area examined. Levels of the dopamine metabolite, 3,4-dihydroxyphenylacetic acid, were increased only in the VTA and medial prefrontal cortex. These data suggest that neurotensin in the VTA may be involved in environmentally elicited activation of certain mesotelencephalic dopamine neurons.

MeSH Terms (14)

3,4-Dihydroxyphenylacetic Acid Animals Brain Corticotropin-Releasing Hormone Dopamine Electroshock Male Neurotensin Rats Rats, Inbred Strains Somatostatin Stress, Physiological Tegmentum Mesencephali Telencephalon

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