mGlu potentiation rescues cognitive, social, and respiratory phenotypes in a mouse model of Rett syndrome.

Gogliotti RG, Senter RK, Fisher NM, Adams J, Zamorano R, Walker AG, Blobaum AL, Engers DW, Hopkins CR, Daniels JS, Jones CK, Lindsley CW, Xiang Z, Conn PJ, Niswender CM
Sci Transl Med. 2017 9 (403)

PMID: 28814546 · PMCID: PMC5654528 · DOI:10.1126/scitranslmed.aai7459

MeSH Terms (25)

Animals Apnea Autopsy CA1 Region, Hippocampal Cognition Disease Models, Animal Dose-Response Relationship, Drug Female Humans Long-Term Potentiation Male Memory Methyl-CpG-Binding Protein 2 Mice Motor Cortex Neuronal Plasticity Phenotype Picolinic Acids Rats, Sprague-Dawley Receptors, Metabotropic Glutamate Respiration Rett Syndrome RNA, Messenger Social Behavior Transcription, Genetic

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