Loss of claudin-3 expression induces IL6/gp130/Stat3 signaling to promote colon cancer malignancy by hyperactivating Wnt/β-catenin signaling.

Ahmad R, Kumar B, Chen Z, Chen X, Müller D, Lele SM, Washington MK, Batra SK, Dhawan P, Singh AB
Oncogene. 2017 36 (47): 6592-6604

PMID: 28783170 · PMCID: PMC6512312 · DOI:10.1038/onc.2017.259

MeSH Terms (21)

Adenocarcinoma Animals beta Catenin Carcinogenesis Cell Transformation, Neoplastic Claudin-3 Colon Colonic Neoplasms Colorectal Neoplasms Cytokine Receptor gp130 Epigenesis, Genetic Epithelial-Mesenchymal Transition Gene Expression Regulation, Neoplastic Humans Intestinal Mucosa Mice Mice, Knockout Permeability STAT3 Transcription Factor Up-Regulation Wnt Signaling Pathway

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