Effects of amnesic doses of reserpine or syrosingopine on mouse brain acetylcholine levels.

Palfai T, Wichlinski L, Brown HA, Brown OM
Pharmacol Biochem Behav. 1986 24 (5): 1457-9

PMID: 2873591 · DOI:10.1016/0091-3057(86)90210-8

The effects of reserpine and syrosingopine on mouse whole brain acetylcholine levels were examined. At 2 or 24 hr following injection, the brains were removed and analyzed by mass spectrometry. No differences were found between drug-treated and control mice in the acetylcholine content of the brain at either time interval. The results suggest that whole brain acetylcholine levels do not predict the amnesic effects of either reserpine or syrosingopine.

MeSH Terms (8)

Acetylcholine Amnesia Animals Brain Gas Chromatography-Mass Spectrometry Male Mice Reserpine

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