Concordance of Beta-papillomavirus across anogenital and oral anatomic sites of men: The HIM Study.

Nunes EM, López RVM, Sudenga SL, Gheit T, Tommasino M, Baggio ML, Ferreira S, Galan L, Silva RC, Lazcano-Ponce E, Giuliano AR, Villa LL, Sichero L, HIM Study group
Virology. 2017 510: 55-59

PMID: 28708973 · PMCID: PMC6561082 · DOI:10.1016/j.virol.2017.07.006

We evaluated the concordance between β-HPVs detected in external genital skin, anal canal, and oral cavity specimens collected simultaneously from 717 men that were participating in the multinational HIM Study. Viral genotyping was performed using the Luminex technology. Species- and type-specific concordance was measured using kappa statistics for agreement. Overall, concordance of β-HPVs across sites was low and mainly observed among paired genital/anal canal samples. When grouped by species, solely β-4 HPVs showed moderate concordance in genital/anal pairs (κ = 0.457), which could be attributed to the substantial concordance of HPV-92 in men from Brazil and Mexico (κ > 0.610). β-HPV type concordance was higher in Mexico, where HPV-19 was consistently concordant in all anatomic site combinations. Our analysis indicates that type-specific concordance across sites is limited to few viral types; however, these infections seem to occur more often than would be expected by chance, suggesting that although rare, there is agreement among sites.

Copyright © 2017 Elsevier Inc. All rights reserved.

MeSH Terms (13)

Anal Canal Betapapillomavirus Brazil Florida Genitalia, Male Genotype Genotyping Techniques Homosexuality, Male Humans Male Mexico Mouth Mucosa Papillomavirus Infections

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