Defective Sphingosine-1-phosphate metabolism is a druggable target in Huntington's disease.

Di Pardo A, Amico E, Basit A, Armirotti A, Joshi P, Neely MD, Vuono R, Castaldo S, Digilio AF, Scalabrì F, Pepe G, Elifani F, Madonna M, Jeong SK, Park BM, D'Esposito M, Bowman AB, Barker RA, Maglione V
Sci Rep. 2017 7 (1): 5280

PMID: 28706199 · PMCID: PMC5509685 · DOI:10.1038/s41598-017-05709-y

MeSH Terms (15)

Aged Aldehyde-Lyases Animals Disease Models, Animal Enzyme Inhibitors Gene Expression Regulation Humans Huntington Disease Lysophospholipids Male Mice Molecular Targeted Therapy Phosphotransferases (Alcohol Group Acceptor) Receptors, Lysosphingolipid Sphingosine

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