Human mitochondrial cytochrome P450 27C1 is localized in skin and preferentially desaturates -retinol to 3,4-dehydroretinol.

Johnson KM, Phan TTN, Albertolle ME, Guengerich FP
J Biol Chem. 2017 292 (33): 13672-13687

PMID: 28701464 · PMCID: PMC5566523 · DOI:10.1074/jbc.M116.773937

MeSH Terms (21)

Biocatalysis Cytochrome P450 Family 27 Diterpenes Gene Expression Profiling Gene Expression Regulation, Enzymologic Humans Hydrogenation Hydroxylation Isoenzymes Kinetics Mitochondria Molecular Structure Organ Specificity Oxidation-Reduction Peptide Fragments Proteolysis Proteomics Skin Stereoisomerism Substrate Specificity Vitamin A

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