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To Avoid Chasing Incorrect Chemical Structures of Chiral Compounds: Raman Optical Activity and Vibrational Circular Dichroism Spectroscopies.

Polavarapu PL, Covington CL, Raghavan V
Chemphyschem. 2017 18 (18): 2459-2465

PMID: 28700810 · DOI:10.1002/cphc.201700764

A chemical structure (CS) identifies the connectivities between atoms, and the nature of those connections, for a given elemental composition. For chiral molecules, in addition to the identification of CS, the identification of the correct absolute configuration (AC) is also needed. Several chiral natural products are known whose CSs were initially misidentified and later corrected, and these errors were often discovered during the total synthesis of natural products. In this work, we present a new and convenient approach that can be used with Raman optical activity (ROA) and vibrational circular dichroism (VCD) spectroscopies, to distinguish between the correct and incorrect CSs of chiral compounds. This approach involves analyzing the spectral similarity overlap between experimental spectra and those predicted with advanced quantum chemical theories. Significant labor needed for establishing the correct CSs via chemical syntheses of chiral natural products can thus be avoided.

© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

MeSH Terms (10)

Alcohols Alkynes Circular Dichroism Furans Ketones Lactones Molecular Structure Quantum Theory Sesquiterpenes Spectrum Analysis, Raman

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