Pharmacologic Inhibition of β-Catenin With Pyrvinium Inhibits Murine and Human Models of Wilms Tumor.

Polosukhina D, Love HD, Moses HL, Lee E, Zent R, Clark PE
Oncol Res. 2017 25 (9): 1653-1664

PMID: 28695795 · PMCID: PMC5670010 · DOI:10.3727/096504017X14992942781895

Wilms tumor (WT) is the most common renal malignancy in children and the fourth most common pediatric solid malignancy in the US. Although the mechanisms underlying the WT biology are complex, these tumors most often demonstrate activation of the canonical Wnt/β-catenin pathway. We and others have shown that constitutive activation of β-catenin restricted to the renal epithelium is sufficient to induce primitive renal epithelial tumors, which resemble human WT. Here we demonstrate that pharmacologic inhibition of β-catenin gene transcription with pyrvinium inhibits tumor growth and metastatic progression in a murine model of WT. Cellular invasion is significantly inhibited in both murine WT-like and human WT cells and is accompanied by downregulation of the oncogenes Myc and Birc5 (survivin). Our studies provide proof of the concept that the canonical Wnt/β-catenin pathway may be a novel therapeutic target in the management of WT.

MeSH Terms (13)

Animals Anthelmintics beta Catenin Cell Line, Tumor Cell Proliferation Disease Models, Animal Humans Mice Pyrvinium Compounds Signal Transduction Transcription, Genetic Wilms Tumor Wnt Signaling Pathway

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