Multiresponsive Nanogels for Targeted Anticancer Drug Delivery.

Zhang Q, Colazo J, Berg D, Mugo SM, Serpe MJ
Mol Pharm. 2017 14 (8): 2624-2628

PMID: 28686454 · DOI:10.1021/acs.molpharmaceut.7b00325

Nanogels with a biomolecular coating (biocoating) were shown to be capable of triggered delivery of anticancer drug Doxorubicin. The biocoating was formed utilizing binding between glycogen and the tetra-functional lectin Concanavalin A, which can be triggered to disassemble (and release) upon exposure to glucose and changes in solution pH. We also show the nanogel's thermoresponsivity can be used to accelerate Doxorubicin release. Moreover, we showed that transferrin immobilized on the nanogel surface could accelerate nanogel uptake by cancer cells. In these experiments, we showed that Doxorubicin was able to be released to the nucleus of human liver cancer cell line (HepG2) within 3 h. Doxorubicin-loaded nanogels exhibit a strong growth inhibition ability toward HepG2. This investigation showcases how nanogel design and chemistry can be tuned to achieve useful biomedical applications.

MeSH Terms (13)

Antineoplastic Agents Cell Survival Concanavalin A Doxorubicin Drug Carriers Hep G2 Cells Humans Hydrogen-Ion Concentration Nanogels Nanoparticles Polyethylene Glycols Polyethyleneimine Polymers

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