Restoring auditory cortex plasticity in adult mice by restricting thalamic adenosine signaling.

Blundon JA, Roy NC, Teubner BJW, Yu J, Eom TY, Sample KJ, Pani A, Smeyne RJ, Han SB, Kerekes RA, Rose DC, Hackett TA, Vuppala PK, Freeman BB, Zakharenko SS
Science. 2017 356 (6345): 1352-1356

PMID: 28663494 · PMCID: PMC5523828 · DOI:10.1126/science.aaf4612

Circuits in the auditory cortex are highly susceptible to acoustic influences during an early postnatal critical period. The auditory cortex selectively expands neural representations of enriched acoustic stimuli, a process important for human language acquisition. Adults lack this plasticity. Here we show in the murine auditory cortex that juvenile plasticity can be reestablished in adulthood if acoustic stimuli are paired with disruption of ecto-5'-nucleotidase-dependent adenosine production or A-adenosine receptor signaling in the auditory thalamus. This plasticity occurs at the level of cortical maps and individual neurons in the auditory cortex of awake adult mice and is associated with long-term improvement of tone-discrimination abilities. We conclude that, in adult mice, disrupting adenosine signaling in the thalamus rejuvenates plasticity in the auditory cortex and improves auditory perception.

Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

MeSH Terms (15)

5'-Nucleotidase Adenosine Adenosine A1 Receptor Agonists Adenosine A1 Receptor Antagonists Animals Auditory Cortex Auditory Perception GPI-Linked Proteins Mice Neuronal Plasticity Piperidines Pyridazines Receptor, Adenosine A1 Signal Transduction Thalamus

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