Differential abundance of CK1α provides selectivity for pharmacological CK1α activators to target WNT-dependent tumors.

Li B, Orton D, Neitzel LR, Astudillo L, Shen C, Long J, Chen X, Kirkbride KC, Doundoulakis T, Guerra ML, Zaias J, Fei DL, Rodriguez-Blanco J, Thorne C, Wang Z, Jin K, Nguyen DM, Sands LR, Marchetti F, Abreu MT, Cobb MH, Capobianco AJ, Lee E, Robbins DJ
Sci Signal. 2017 10 (485)

PMID: 28655862 · PMCID: PMC5555225 · DOI:10.1126/scisignal.aak9916

MeSH Terms (24)

Animals Antineoplastic Agents Benzoates Casein Kinase Ialpha Enzyme Activation Enzyme Activators Gene Expression Regulation, Neoplastic HCT116 Cells Humans Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Nude Neoplasm Metastasis Neoplasms Organ Culture Techniques Phosphorylation Pyrvinium Compounds Signal Transduction Surface Plasmon Resonance Wnt Proteins Wnt Signaling Pathway Xenograft Model Antitumor Assays Xenopus laevis

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