Sulzer D, Alcalay RN, Garretti F, Cote L, Kanter E, Agin-Liebes J, Liong C, McMurtrey C, Hildebrand WH, Mao X, Dawson VL, Dawson TM, Oseroff C, Pham J, Sidney J, Dillon MB, Carpenter C, Weiskopf D, Phillips E, Mallal S, Peters B, Frazier A, Lindestam Arlehamn CS, Sette A
Nature. 2017 546 (7660)
· PMCID: PMC5626019
Genetic studies have shown the association of Parkinson's disease with alleles of the major histocompatibility complex. Here we show that a defined set of peptides that are derived from α-synuclein, a protein aggregated in Parkinson's disease, act as antigenic epitopes displayed by these alleles and drive helper and cytotoxic T cell responses in patients with Parkinson's disease. These responses may explain the association of Parkinson's disease with specific major histocompatibility complex alleles.
MeSH Terms (17)Aged Aged, 80 and over Alleles alpha-Synuclein Amino Acid Sequence Autoimmunity Epitopes, T-Lymphocyte Female HLA Antigens Humans Male Middle Aged Parkinson Disease Peptide Fragments T-Lymphocytes T-Lymphocytes, Cytotoxic T-Lymphocytes, Helper-Inducer