Discovery and optimization of 3-(4-aryl/heteroarylsulfonyl)piperazin-1-yl)-6-(piperidin-1-yl)pyridazines as novel, CNS penetrant pan-muscarinic antagonists.

Bender AM, Weiner RL, Luscombe VB, Ajmera S, Cho HP, Chang S, Zhan X, Rodriguez AL, Niswender CM, Engers DW, Bridges TM, Conn PJ, Lindsley CW
Bioorg Med Chem Lett. 2017 27 (15): 3576-3581

PMID: 28633897 · PMCID: PMC6659418 · DOI:10.1016/j.bmcl.2017.05.042

MeSH Terms (12)

Animals Brain CHO Cells Cricetulus Humans Muscarinic Antagonists Piperazine Piperazines Pyridazines Rats Receptor, Muscarinic M4 Structure-Activity Relationship

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