Oxygen sensors as therapeutic targets in kidney disease.

Haase VH
Nephrol Ther. 2017 13 Suppl 1: S29-S34

PMID: 28577740 · DOI:10.1016/j.nephro.2017.01.015

Hypoxia is a common clinical problem that has profound effects on renal homeostasis. Prolyl-4-hydroxylases PHD1, 2 and 3 function as oxygen sensors and control the activity of hypoxia-inducible factor (HIF), an oxygen-sensitive transcription factor that regulates a multitude of hypoxia responses, which help cells and tissues to adapt to low oxygen environments. This review provides an overview of the molecular mechanisms that govern these hypoxia responses and discusses clinical experience with compounds that inhibit prolyl-4-hydroxylases to harness HIF responses for therapy in nephrology.

Copyright © 2017 Société francophone de néphrologie, dialyse et transplantation. Published by Elsevier Masson SAS. All rights reserved.

MeSH Terms (9)

Erythropoietin Homeostasis Humans Hypoxia Hypoxia-Inducible Factor-Proline Dioxygenases Kidney Oxygen Prolyl-Hydroxylase Inhibitors Renal Insufficiency, Chronic

Connections (1)

This publication is referenced by other Labnodes entities: