Heme-thiolate sulfenylation of human cytochrome P450 4A11 functions as a redox switch for catalytic inhibition.

Albertolle ME, Kim D, Nagy LD, Yun CH, Pozzi A, Savas Ü, Johnson EF, Guengerich FP
J Biol Chem. 2017 292 (27): 11230-11242

PMID: 28533430 · PMCID: PMC5500791 · DOI:10.1074/jbc.M117.792200

MeSH Terms (14)

Animals Catalysis Cytochrome P-450 CYP4A Dithiothreitol Heme Humans Hydrogen Peroxide Hydroxyeicosatetraenoic Acids Kidney Liver Mice Mice, Transgenic Oxidation-Reduction Rats

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