Gβγ directly modulates vesicle fusion by competing with synaptotagmin for binding to neuronal SNARE proteins embedded in membranes.

Zurawski Z, Page B, Chicka MC, Brindley RL, Wells CA, Preininger AM, Hyde K, Gilbert JA, Cruz-Rodriguez O, Currie KPM, Chapman ER, Alford S, Hamm HE
J Biol Chem. 2017 292 (29): 12165-12177

PMID: 28515322 · PMCID: PMC5519367 · DOI:10.1074/jbc.M116.773523

MeSH Terms (24)

Animals Binding, Competitive Calcium Signaling Cattle Cell Line GTP-Binding Protein beta Subunits GTP-Binding Protein gamma Subunits Humans Lipid Bilayers Liposomes Membrane Fusion Models, Molecular Mutation Nerve Tissue Proteins Peptide Fragments Protein Conformation Protein Interaction Domains and Motifs Protein Multimerization Rats Recombinant Fusion Proteins Recombinant Proteins Synaptosomal-Associated Protein 25 Synaptotagmin I Syntaxin 1

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