Induction of human cytochrome P450 3A enzymes in cultured placental cells by thalidomide and relevance to bioactivation and toxicity.

Murayama N, Kazuki Y, Satoh D, Arata K, Harada T, Shibata N, Guengerich FP, Yamazaki H
J Toxicol Sci. 2017 42 (3): 343-348

PMID: 28496040 · PMCID: PMC5776038 · DOI:10.2131/jts.42.343

MeSH Terms (14)

Cells, Cultured Cytochrome P-450 CYP3A Enzyme Induction Female Humans Liver Oxidation-Reduction Placenta Pregnancy Pregnane X Receptor Receptors, Steroid Rifampin RNA, Messenger Thalidomide

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