Chronicle of a Neuronal Death Foretold: Preventing Aging by Keeping MGRN1 at the Nucleus.

Ortolano NA, Gama V
Mol Cell. 2017 66 (3): 301-303

PMID: 28475865 · DOI:10.1016/j.molcel.2017.04.014

In this issue of Molecular Cell, Benvegnù et al. (2017) report an unexpected phenomenon by which the E3 ligase mahogunin ring finger-1 (MGRN1) translocates to the nucleus in an age-dependent manner, revealing an intriguing mechanism that allows for an adaptive neuronal response to proteotoxic stress, often seen with aging.

Copyright © 2017 Elsevier Inc. All rights reserved.

MeSH Terms (1)

Ubiquitin-Protein Ligases

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