Crystal Structure of the New Investigational Drug Candidate VT-1598 in Complex with Aspergillus fumigatus Sterol 14α-Demethylase Provides Insights into Its Broad-Spectrum Antifungal Activity.

Hargrove TY, Garvey EP, Hoekstra WJ, Yates CM, Wawrzak Z, Rachakonda G, Villalta F, Lepesheva GI
Antimicrob Agents Chemother. 2017 61 (7)

PMID: 28461309 · PMCID: PMC5487673 · DOI:10.1128/AAC.00570-17

MeSH Terms (12)

Antifungal Agents Aspergillus fumigatus Candida albicans Drugs, Investigational Fluconazole Ketoconazole Microbial Sensitivity Tests Pyridines Sterol 14-Demethylase Tetrazoles Triazoles Voriconazole

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