Optimization of M positive allosteric modulators (PAMs): The discovery of VU0476406, a non-human primate in vivo tool compound for translational pharmacology.

Melancon BJ, Wood MR, Noetzel MJ, Nance KD, Engelberg EM, Han C, Lamsal A, Chang S, Cho HP, Byers FW, Bubser M, Jones CK, Niswender CM, Wood MW, Engers DW, Wu D, Brandon NJ, Duggan ME, Conn PJ, Bridges TM, Lindsley CW
Bioorg Med Chem Lett. 2017 27 (11): 2296-2301

PMID: 28442253 · PMCID: PMC5508548 · DOI:10.1016/j.bmcl.2017.04.043

MeSH Terms (10)

Allosteric Regulation Animals Crystallography, X-Ray Drug Discovery Hydrogen Bonding Pyridazines Rats Structure-Activity Relationship Thiophenes Translational Research, Biomedical

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