Synthesis and evaluation of 4,6-disubstituted pyrimidines as CNS penetrant pan-muscarinic antagonists with a novel chemotype.

Bender AM, Weiner RL, Luscombe VB, Cho HP, Niswender CM, Engers DW, Bridges TM, Conn PJ, Lindsley CW
Bioorg Med Chem Lett. 2017 27 (11): 2479-2483

PMID: 28427812 · PMCID: PMC5508519 · DOI:10.1016/j.bmcl.2017.04.009

MeSH Terms (12)

Animals Brain Humans Inhibitory Concentration 50 Muscarinic Antagonists Protein Binding Pyrimidines Rats Receptor, Muscarinic M4 Receptors, Muscarinic Recombinant Proteins Structure-Activity Relationship

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