The major miR-31 target genes STK40 and LATS2 and their implications in the regulation of keratinocyte growth and hair differentiation.

Luan L, Shi J, Yu Z, Andl T
Exp Dermatol. 2017 26 (6): 497-504

PMID: 28419554 · DOI:10.1111/exd.13355

Emerging evidence indicates that even subtle changes in the expression of key genes of signalling pathways can have profound effects. MicroRNAs (miRNAs) are masters of subtlety and generally have only mild effects on their target genes. The microRNA miR-31 is one of the major microRNAs in many cutaneous conditions associated with activated keratinocytes, such as the hyperproliferative diseases psoriasis, non-melanoma skin cancer and hair follicle growth. miR-31 is a marker of the hair growth phase, and in our miR-31 transgenic mouse model it impairs the function of keratinocytes. This leads to aberrant proliferation, apoptosis, and differentiation that results in altered hair growth, while the loss of miR-31 leads to increased hair growth. Through in vitro and in vivo studies, we have defined a set of conserved miR-31 target genes, including LATS2 and STK40, which serve as new players in the regulation of keratinocyte growth and hair follicle biology. LATS2 can regulate growth of keratinocytes and we have identified a function of STK40 that can promote the expression of key hair follicle programme regulators such as HR, DLX3 and HOXC13.

© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

MeSH Terms (22)

3' Untranslated Regions Adaptor Proteins, Signal Transducing Animals Apoptosis Carcinoma, Basal Cell Cell Differentiation Cell Line, Tumor Cell Proliferation Cell Survival Hair Follicle Homeodomain Proteins Humans Intracellular Signaling Peptides and Proteins Keratinocytes Mice Mice, Transgenic MicroRNAs Protein-Serine-Threonine Kinases Skin Skin Neoplasms Transcription Factors Tumor Suppressor Proteins

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