Camptothecin resistance is determined by the regulation of topoisomerase I degradation mediated by ubiquitin proteasome pathway.

Ando K, Shah AK, Sachdev V, Kleinstiver BP, Taylor-Parker J, Welch MM, Hu Y, Salgia R, White FM, Parvin JD, Ozonoff A, Rameh LE, Joung JK, Bharti AK
Oncotarget. 2017 8 (27): 43733-43751

PMID: 28415827 · PMCID: PMC5546437 · DOI:10.18632/oncotarget.16376

MeSH Terms (19)

BRCA1 Protein Camptothecin Cell Line, Tumor DNA-Binding Proteins DNA Topoisomerases, Type I Drug Resistance, Neoplasm Gene Editing Humans Ku Autoantigen Multiprotein Complexes Phosphorylation Proteasome Endopeptidase Complex Protein Binding Protein Kinase C Proteolysis PTEN Phosphohydrolase RNA Interference Topoisomerase I Inhibitors Ubiquitin

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