Combinatorial optimization of PEG architecture and hydrophobic content improves ternary siRNA polyplex stability, pharmacokinetics, and potency in vivo.

Werfel TA, Jackson MA, Kavanaugh TE, Kirkbride KC, Miteva M, Giorgio TD, Duvall C
J Control Release. 2017 255: 12-26

PMID: 28366646 · PMCID: PMC5484420 · DOI:10.1016/j.jconrel.2017.03.389

MeSH Terms (13)

Animals Cell Line Cell Line, Tumor Female Humans Hydrophobic and Hydrophilic Interactions Luciferases Methacrylates Mice Mice, Nude Polyethylene Glycols RNA, Small Interfering Tissue Distribution

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