Factors Associated With Pre- and Postoperative Seizures in 1033 Patients Undergoing Supratentorial Meningioma Resection.

Chen WC, Magill ST, Englot DJ, Baal JD, Wagle S, Rick JW, McDermott MW
Neurosurgery. 2017 81 (2): 297-306

PMID: 28327947 · PMCID: PMC5572484 · DOI:10.1093/neuros/nyx001

BACKGROUND - Risk factors for pre- and postoperative seizures in supratentorial meningiomas are understudied compared to other brain tumors.

OBJECTIVE - To report seizure frequency and identify factors associated with pre- and postoperative seizures in a large single-center population study of patients undergoing resection of supratentorial meningioma.

METHODS - Retrospective chart review of 1033 subjects undergoing resection of supratentorial meningioma at the author's institution (1991-2014). Multivariate regression was used to identify variables significantly associated with pre- and postoperative seizures.

RESULTS - Preoperative seizures occurred in 234 (22.7%) subjects. At 5 years postoperative, probability of seizure freedom was 89.9% among subjects without preoperative seizures and 62.2% with preoperative seizures. Multivariate analysis identified the following predictors of preoperative seizures: presence of  ≥1 cm peritumoral edema (odds ratio [OR]: 4.45, 2.55-8.50), nonskull base tumor location (OR: 2.13, 1.26-3.67), greater age (OR per unit increase: 1.03, 1.01-1.05), while presenting symptom of headache (OR: 0.50, 0.29-0.84) or cranial nerve deficit (OR: 0.36, 0.17-0.71) decreased odds of preoperative seizures. Postoperative seizures after discharge were associated with preoperative seizures (OR: 5.70, 2.57-13.13), in-hospital seizure (OR: 4.31, 1.28-13.67), and among patients without preoperative seizure, occurrence of medical or surgical complications (OR 3.39, 1.09-9.48). Perioperative anti-epileptic drug use was not associated with decreased incidence of postoperative seizures.

CONCLUSIONS - Nonskull base supratentorial meningiomas with surrounding edema have the highest risk for preoperative seizure. Long-term follow-up showing persistent seizures in meningioma patients with preoperative seizures raises the possibility that these patients may benefit from electrocorticographic mapping of adjacent cortex and resection of noneloquent, epileptically active cortex.

Copyright © 2017 by the Congress of Neurological Surgeons

MeSH Terms (12)

Adult Aged Female Humans Male Meningioma Middle Aged Postoperative Complications Retrospective Studies Risk Factors Seizures Supratentorial Neoplasms

Connections (1)

This publication is referenced by other Labnodes entities:

Links