The ErbB3 receptor tyrosine kinase negatively regulates Paneth cells by PI3K-dependent suppression of Atoh1.

Almohazey D, Lo YH, Vossler CV, Simmons AJ, Hsieh JJ, Bucar EB, Schumacher MA, Hamilton KE, Lau KS, Shroyer NF, Frey MR
Cell Death Differ. 2017 24 (5): 855-865

PMID: 28304405 · PMCID: PMC5423110 · DOI:10.1038/cdd.2017.27

MeSH Terms (23)

Animals Basic Helix-Loop-Helix Transcription Factors Cell Communication Cell Count Cell Differentiation Extracellular Signal-Regulated MAP Kinases Female Gene Expression Regulation HT29 Cells Humans Ileum Male MAP Kinase Signaling System Mice Mice, Inbred C57BL Mice, Knockout Paneth Cells Phosphatidylinositol 3-Kinases Proto-Oncogene Proteins c-akt Receptor, ErbB-3 Receptors, G-Protein-Coupled Stem Cell Niche Stem Cells

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