Structure-Based Design of a Soluble Prefusion-Closed HIV-1 Env Trimer with Reduced CD4 Affinity and Improved Immunogenicity.

Chuang GY, Geng H, Pancera M, Xu K, Cheng C, Acharya P, Chambers M, Druz A, Tsybovsky Y, Wanninger TG, Yang Y, Doria-Rose NA, Georgiev IS, Gorman J, Joyce MG, O'Dell S, Zhou T, McDermott AB, Mascola JR, Kwong PD
J Virol. 2017 91 (10)

PMID: 28275193 · PMCID: PMC5411596 · DOI:10.1128/JVI.02268-16

MeSH Terms (12)

AIDS Vaccines Animals Antibodies, Neutralizing CD4 Antigens env Gene Products, Human Immunodeficiency Virus Guinea Pigs HIV-1 HIV Antibodies HIV Antigens Humans Protein Multimerization Protein Stability

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